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M94A2992.TXT
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1994-10-25
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Document 2992
DOCN M94A2992
TI Signet cell carcinoma of the stomach in a patient with AIDS: a case
report.
DT 9412
AU Uchida T; Takamatsu Red Cross Hospital, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):178 (abstract no. PB0139). Unique
Identifier : AIDSLINE ICA10/94369583
AB OBJECTIVE: A case of signet cell cancer associated with AIDS is
presented. CASE HISTORY: A 50-year-old Japanese man with hemophilia A
had required multiple injections of factor VIII concentrate since 1973.
He developed dysphagia, heartburn and hiccups on July 1987. He lost 10kg
in weight during 2 months. No lymph-node swelling or Kaposi's sarcoma
was found. An upper GI series showed an obstruction in the esophageal
region. The biopsy showed signet cell carcinoma. In addition to gastric
cancer, an esophageal candidiasis was also observed in an endoscopic
examination. HIV antibody was positive in gp160, 120, 41, p55, 32, 24,
18 by WB. The HIV antigen was negative. Twenty days after his admission,
febrile condition reached a continuous 40C. Cultures of blood grew
candida species. CD4 lymphocytes decreased by less than 400/ul since the
end of October. His massive hemorrhage from the gastric cancer continued
and he died on November 24, 1987. DISCUSSION AND CONCLUSIONS: Signet
cell carcinoma is not one of the cancers typically seen in AIDS. It is
possible that the patient had a coincidental carcinoma along with AIDS.
It is suggested, however, that the HIV infection had a role in causing
the signet cell carcinoma, giving rise to its classification as an
opportunistic tumor.
DE Acquired Immunodeficiency Syndrome/*DIAGNOSIS/TRANSMISSION AIDS
Serodiagnosis AIDS-Related Opportunistic Infections/DIAGNOSIS
Candidiasis/DIAGNOSIS Carcinoma, Signet Ring Cell/DIAGNOSIS Case
Report Factor VIII/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS
Hemophilia/THERAPY Human HIV Antibodies/ANALYSIS Male Middle Age
Stomach Neoplasms/*DIAGNOSIS MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).